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目的 用13 N NH3 PET动态显像研究正常垂体血流灌注和NH3 代谢功能。方法 2 1例受检者均无垂体相关病史 ,行13 N NH3 PET显像 ,其中 6例进行了13 N NH3 PET动态显像 ,8例同时行脑MRI检查 ,并进行MRI和PET图像融合。结果 13 N NH3 PET显像示垂体清晰显影 ,大小为 (1.0 7±0 17)cm× (1.0 9± 0 .15 )cm× (1.14± 0 .17)cm。垂体13 N NH3 标准摄取值 (SUV)为 3.84± 1.75 ,与丘脑放射性比值为 1.35± 0 .6 3。垂体动态显像均在颈内动脉显像后 10s内显影 ,13 N NH3 在垂体内明显滞留 ,2 0min内放射性无明显清除。颈内动脉显影达高峰时 ,垂体 /颈内动脉放射性比值为 0 .75±0 .13。结论 动态13 N NH3 PET显像可反映垂体血流灌注情况。垂体细胞摄取13 N NH3 ,NH3 参与垂体细胞代谢。
Objective To study the normal pituitary perfusion and NH3 metabolism by 13 N NH3 PET dynamic imaging. Twenty-one subjects had no pituitary-related medical history. 13N NH3 PET imaging was performed. Among them, 6 patients underwent 13 N NH3 PET dynamic imaging and 8 patients underwent brain MRI simultaneously. MRI and PET image fusion were performed. Results 13N NH3 PET imaging showed clear development of the pituitary, the size of (1.07 ± 0.17) cm × (1.09 ± 0.15) cm × (1.14 ± 0.17) cm. The pituitary 13 N NH3 standard uptake (SUV) was 3.84 ± 1.75, and the thalamus radioactivity ratio was 1.35 ± 0.6. Dynamic imaging of pituitary gland developed within 10s after internal carotid artery imaging. 13N NH3 was well retained in the pituitary gland and no obvious radioactivity was observed within 20 min. When the peak of internal carotid artery imaging peaked, the ratio of pituitary / internal carotid artery radioactivity was 0.75 ± 0.13. Conclusion Dynamic 13 N NH3 PET imaging can reflect the situation of pituitary perfusion. Pituitary cells uptake 13 N NH3, NH3 involved in pituitary cell metabolism.