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目的:探讨临床药师在参与抗感染治疗中实施个体化给药方案设计的临床疗效及意义。方法:分别为4例泛耐药铜绿假单胞菌感染、肾功能不全合并曲霉菌感染、泛耐药肺炎克雷伯菌感染、肾移植术后新生隐球菌脑膜炎感染患者设计个体化抗感染治疗方案,并对临床疗效进行评价。结果:经临床药师参与治疗的典型案例,取得较为满意的临床治疗效果。结论:临床药师参与个体化抗感染治疗,在提高临床治疗效果的同时,也解答了临床医师关于抗感染药物方面的疑问,使临床药学工作逐步得到临床认可。
OBJECTIVE: To investigate the clinical efficacy and significance of clinical pharmacists in the design of individualized dosing regimens in participating in anti-infective therapy. Methods: Individualized anti-infectives were designed for 4 patients with pan-resistant Pseudomonas aeruginosa infection, renal insufficiency with Aspergillus infection, pan-drug resistant Klebsiella pneumoniae infection, and Cryptococcus neoformans meningitis after renal transplantation Treatment plan, and evaluate the clinical efficacy. Results: The clinical pharmacists involved in the treatment of typical cases, to obtain more satisfactory results of clinical treatment. Conclusion: The participation of clinical pharmacists in individualized anti-infective therapy has not only improved the clinical therapeutic effect, but also solved the clinicians’ questions about anti-infective drugs and gradually gained clinical approval of clinical pharmacy work.