非霍奇金淋巴瘤(NHL)是我国较多见的,起源于淋巴结及淋巴组织的恶性肿瘤,其发病率和病死率已居恶性肿瘤第5位。其中恶性程度较高,进展较快的侵袭性NHL又占有较大的的比例。20多年来,该病治疗主要以CHOP方案为一线的标准治疗方案,但治疗效果并不理想,近几年 Non-Hodgkin’s lymphoma (NHL) is more common in our country, originated in lymph nodes and lymphoid tissue malignancies, the incidence and mortality rate ranks fifth in malignant tumors. Among them, aggressive NHL, which has a higher malignancy and progresses faster, occupies a larger proportion. For more than 20 years, the treatment of the disease is mainly based on the CHOP program as the first line of standard treatment, but the treatment effect is not ideal. In recent years