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目的 探明犬心脏表面神经丛的化学特性。 方法 免疫组织化学ABC法。 结果 在犬心脏表面各神经丛均见降钙素基因相关肽 (CGRP)免疫反应阳性神经元 ,而SP免疫阳性神经元仅在心房背侧神经丛(DAP)、房间隔神经丛 (IAP)和主动脉 肺动脉间神经丛 (A PP)内见到。CGRP IR和SP IR神经元形态、大小相似。心房表面神经丛内的CGRP IR和SP IR神经元都较心室表面神经丛者多。在心脏表面各脂肪垫及心肌间隙等处见到多量CGRP IR、SP IR神经纤维 ,多靠近血管或附于血管壁 ,在一些部位可见这两种肽能神经纤维似与心肌细胞接触。 结论 犬心脏表面神经丛内存在CGRP和SP ;其在心脏内执行的功能可能有联系或相似之处 ,但也有不同 ;两种肽能神经对心房和心室的支配不对称 ,提示CGRP和SP可能直接参与心肌细胞和心脏血管活动的调控。
Objective To explore the chemical properties of canine plexus surface. Methods Immunohistochemical ABC method. RESULTS: CGRP immunoreactive neurons were found in all nerve plexus on the surface of canine heart, whereas SP immunoreactive neurons were only found in antral atrial dorsal plexus (AAP), atrial septal plexus (IAP) and Aortic Pulmonary Plexus (A PP) seen. CGRP IR and SP IR neuronal morphology, size similar. There were more CGRP IR and SP IR neurons in the atrial surface plexus than in the ventricular surface plexus. A large amount of CGRP IR and SPIR nerve fibers were seen on the fat pads and myocardial interspaces of the heart, etc., and more or less close to the blood vessels or attached to the blood vessel wall. These two kinds of peptide nerve fibers can be seen to be in contact with cardiomyocytes in some areas. Conclusions The presence of CGRP and SP in the cardiac plexus of the canine; the functions performed in the heart may or may not be the same; however, the asymmetry of atrial and ventricular dyssynaptic nerves in both canine nerves suggests that CGRP and SP may be Directly involved in the regulation of myocardial cells and cardiovascular activity.