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目的:探讨胃癌组织中人端粒酶逆转录酶(hTERT)、血管内皮生长因子(VEGF)表达与微血管密度(MVD)的相关性及其临床意义。方法:采用超敏SP法检测138例胃癌的hTERT、VEGF表达和肿瘤MVD,结合临床病理学特征进行相关分析。结果:本组胃癌组织hTERT表达阳性率为81.2%(112/138),VEGF表达阳性率为85.5%(118/138),MVD平均为45.8。hTERT阳性表达与胃癌的浸润深度、淋巴结状态、临床分期具有相关性,VEGF阳性表达与组织学分化型、淋巴结转移、血管浸润相关,MVD与浸润深度、淋巴结状态相关;VEGF表达与MVD值存在显著性意义。结论:hTERT激活与VEGF表型在胃癌进程中发挥重要作用,检测hTERT、VEGF表达和MVD,对胃癌诊断和预后的判断具有一定的价值。
Objective: To investigate the correlation between telomerase reverse transcriptase (hTERT), vascular endothelial growth factor (VEGF) expression and microvessel density (MVD) in gastric carcinoma and its clinical significance. Methods: The hTERT, VEGF expression and tumor MVD in 138 cases of gastric cancer were detected by the method of hypersensitive SP method. The correlation analysis was performed with the clinicopathological features. Results: The positive rate of hTERT expression in gastric cancer tissues was 81.2% (112/138). The positive rate of VEGF expression was 85.5% (118/138). The average MVD was 45.8. The positive expression of hTERT was correlated with the depth of invasion, lymph node status and clinical stage of gastric cancer. The positive expression of VEGF was correlated with histological differentiation, lymph node metastasis and vascular invasion, and the MVD was correlated with the depth of invasion and lymph node status. The expression of VEGF was significantly correlated with MVD Sexual meaning. Conclusion: The activation of hTERT and the phenotype of VEGF play an important role in the progression of gastric cancer. Detecting the expression of hTERT, VEGF and MVD has some value in the diagnosis and prognosis of gastric cancer.