由于现有的口服全菌体伤寒沙门菌Ty21a和注射Vi荚膜多糖疫苗的保护效力很不理想,也没有抗副伤寒或非伤寒沙门菌(NTS)血清型的疫苗,应该探讨新的方法。由两个伤寒疫苗诱导的免疫学机制主要针对不同的结构。作者研究了同时使用这两种疫苗是否会提高伤寒沙门菌特异性免疫应答和抗其他沙门菌交叉应答。志愿者同时接种Ty21a和Vi疫苗(Ty21a+Vi组)或单独接种(Ty21a组和Vi组)。所有的志愿者 Because of the poor protective efficacy of the existing oral all-cell Salmonella typhi Ty21a and Vi capsular polysaccharide vaccines against vaccines against paratyphoid or non-salmonella typhimurium (NTS) serotypes, new approaches should be explored. The immunological mechanisms induced by the two typhoid vaccines are mainly aimed at different structures. The authors investigated whether using both vaccines at the same time could improve Salmonella typhimurium-specific immune responses and against other Salmonella cross-reactions. The volunteers were vaccinated with both Ty21a and Vi vaccines (Ty21a + Vi) or vaccinated alone (Ty21a and Vi). All volunteers