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目的持续监测慢性阻塞性肺病(COPD)患者进餐时脉氧饱和度(SpO2),并探讨其临床意义。方法2004-11~2005-03对上海新华医院19例COPD患者连续观察其进餐前后脉氧饱和度和胸腹呼吸幅度大小的变化,并测定体重指数(BMI)和肺功能。结果COPD患者餐后SpO2显著低于餐前(P<0.01),胸部呼吸运动在进餐过程中幅度变化差异有显著性(P<0.01)。患者BMI与餐后SpO2呈负相关(P<0.05)。SpO2与肺功能FEV1%及FEV1/FVC存在相关性,而与胸部呼吸波幅变化差异无显著性(P>0.05)。结论COPD患者的营养状况可能与进餐后发生的缺氧,进而导致其摄食减少有关,在营养支持中应考虑采取适当措施干预进餐引起的低氧血症发生。
Objective To continuously monitor the oxygen saturation (SpO2) during mealtime in patients with chronic obstructive pulmonary disease (COPD) and to investigate its clinical significance. Methods From 2004-11 to 2005-03, 19 patients with COPD in Shanghai Xinhua Hospital were continuously monitored for changes in the oxygen saturation and respiratory rate before and after mealtime, and body mass index (BMI) and lung function were measured. Results The postprandial SpO2 of postprandial blood glucose in COPD patients was significantly lower than that before meals (P <0.01). There was a significant difference in amplitude of chest breathing during meal (P <0.01). There was a negative correlation between BMI and postprandial SpO2 (P <0.05). There was a correlation between SpO2 and pulmonary function FEV1% and FEV1 / FVC, but no significant difference between them (P> 0.05). Conclusion The nutritional status of patients with COPD may be related to the hypoxia that occurs after a meal, leading to the reduction of their food intake. Nutritional support should take appropriate measures to interfere with meal-induced hypoxemia.