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目的探讨高血压患者血清中的一氧化氮(NO)、超氧化物歧化酶(SOD)的临床意义。方法选择90例单纯高血压病患者(高血压组),分为血压1级、2级、3级或以上共三个亚组,每组30例;同时根据每个患者性别、年龄、生活职业环境、心血管危险因素配对与健康组作对照组。测定血清一氧化氮和超氧化物歧化酶水平。结果高血压组血清一氧化氮和超氧化物歧化酶水平高于健康人,并随着血压升高而增加,差异有统计学意义(F=7.23,F=6.59,P<0.05)。结论血清一氧化氮和超氧化物歧化酶水平与高血压相关连,与病情进展有关。
Objective To investigate the clinical significance of serum nitric oxide (NO) and superoxide dismutase (SOD) in patients with essential hypertension. Methods Ninety hypertensive patients with hypertension (hypertension group) were divided into three subgroups: one group with blood pressure 1, 2, 3 or above, with 30 cases in each group. At the same time, according to each patient’s gender, age, life occupation Environment and cardiovascular risk factors paired with healthy group as control group. Serum nitric oxide and superoxide dismutase levels were measured. Results The levels of serum nitric oxide and superoxide dismutase in hypertension group were higher than those in healthy people and increased with the increase of blood pressure. The difference was statistically significant (F = 7.23, F = 6.59, P <0.05). Conclusion The levels of serum nitric oxide and superoxide dismutase are associated with hypertension, which are related to the progression of the disease.