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甘氨酸可以合成多种药物,如治疗高血压药物盐酸地拉普利、抑制胃溃疡用碳酸钙制剂、扑热息通甘氨酸盐、单甘氨酸乙酰水杨酸钙、利血胺注射液、抗巴帕金森氏病药物L-多巴、甲砜霉素等。工业级甘氨酸则主要用于大规模生产除草活性最强的除草剂草甘膦。甘氨酸化学合成工艺主要有氯乙酸氨解法、施特雷克法(Strecker)和海因法(Hydantion)三种。目前国内仍采用在国外已被淘汰的氯乙酸氨解法技术,而国外则采用改进的施特雷克法和海因法技术路线。由于原料和工艺的不同,氯乙酸氨解法具有生产成本高,产品质量差的特点,所生产的甘氨酸大多为工业级,纯度一般在95%左右,严重制约了其下游的应用,而国外厂商大多利用丙烯腈副产氢氰酸和羟基乙腈生产甘氨酸,该法生产成本低,产品质量好,一般纯度可以达到99%以上。
Glycine can be synthesized a variety of drugs, such as the treatment of hypertension drugs dexrazapheri hydrochloride, gastric ulcer with calcium carbonate preparations, paracetamol glycinate, glycine monoacetyl calcium salicylate, Jinson disease drugs L-dopa, thiamphenicol and so on. Industrial grade glycine is mainly used for large-scale production of the most herbicidal herbicide glyphosate. Glycine chemical synthesis process are chloroacetic acid ammonia solution, the Strecker and Hydrion (Hydantion) three. At present, the technology of ammonolysis of chloroacetic acid, which has been eliminated in foreign countries, is still adopted in China, while the improved method of Strafik and Heinfa is adopted abroad. Due to the different raw materials and processes, the chloroacetic acid ammonolysis method has the characteristics of high production cost and poor product quality. The produced glycine is mostly industrial grade with the purity being generally around 95%, which seriously restricts the application of the downstream. However, most foreign manufacturers The use of acrylonitrile byproduct hydrocyanic acid and hydroxyacetonitrile production of glycine, the production of low cost, product quality, the general purity can reach more than 99%.