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目的:探讨清热化瘀汤对寻常型银屑病的作用机制。方法:采用小鼠尾部鳞片模型,实验组灌服中药清热化瘀汤,并设立阳性药物对照组和生理盐水空白组,观察鼠尾鳞片颗粒层细胞数。结果:清热化瘀汤的大、小剂量对小鼠尾鳞片颗粒层的形成与生理盐水组比较均有促进作用,差异有统计学意义(P<0.05);清热化瘀汤的大剂量组与甲氨喋呤组比较无统计学意义(P>0.05)。结论:清热化瘀汤可显著促进动物模型颗粒层形成,提示该方在临床上可以纠正银屑病的角化不全。
Objective: To explore the mechanism of Qingre Huayu Decoction on psoriasis vulgaris. METHODS: The mouse tail scales model was used. The experimental group was fed with Qingre Huayu Decoction and a positive drug control group and a normal saline blank group were established to observe the number of rat tail granule cells. RESULTS: The large and small doses of Qingre Huayu Decoction could promote the formation of granular layer of the tail scale of mice compared with that of the normal saline group (P<0.05). The large dose group of Qingre Huayu Decoction The methotrexate group had no statistical significance (P>0.05). Conclusion: Qingrehuayu Decoction can significantly promote the formation of granular layer in animal models, suggesting that this side can correct the parakeratosis of psoriasis in clinical practice.