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本实验通过应用外源ＡＣＴＨ，观察了人参皂甙的内分泌免疫调节效应，实验结果证实，外源ＡＣＴＨ不仅诱发小鼠肾上腺皮质酮分泌增加，同时也导致小鼠ＮＫ细胞活性、Ｔ细胞转化活性的抑制，这种抑制与皮质酮升高水平呈负相关关系。应用人参皂甙可以部分抵消外源ＡＣＴＨ所致肾上腺皮质酮分泌增加，促进ＮＫ细胞以及Ｔ细胞活性恢复。上述结果提示，人参皂甙可以通过调整垂体（ＡＣＴＨ）－肾上腺（皮质酮）轴的活动参与机体免疫功能调节。
In this experiment, exogenous ACTH was used to observe the endocrine and immunomodulatory effects of ginsenosides. The experimental results confirmed that exogenous ACTH not only induces an increase in adrenal corticosterone secretion in mice, but also results in inhibition of mouse NK cell activity and T cell transformation activity. This inhibition was negatively correlated with elevated corticosterone levels. The use of ginsenosides can partially offset the increase of ACTH-induced secretion of corticosterone and promote the recovery of NK cells and T cell activity. The above results suggest that ginsenosides may participate in the regulation of immune function by adjusting the activity of the pituitary (ACTH)-adrenal (corticosterone) axis.