传统的家兔眼刺激试验存在评分主观、结果重复性差和造成动物较大痛苦等缺点。近年来随着“3R”理论的深入人心,各国先后开发了多种眼刺激试验的替代方法。其中离体器官模型在近年来的研究中显示出简便易行、效率较高、预测能力较强等优点,具有较好的应用前景。 Traditional rabbit eye irritation test scores subjective, poor reproducibility of the results and cause greater shortcomings of animals and other shortcomings. In recent years, with the “3R ” theory deeply rooted in people's minds, various countries have developed a variety of alternative methods of eye irritation test. In recent years, ex vivo organ models have shown the advantages of simple and easy to use, high efficiency and strong predictive ability, which has a good prospect of application.