白血病细胞同时显示髓细胞的特征和淋巴细胞特征的白血病,称为双相白血病(Biphenotypic Leukaemia)。它的含义是一个白血病克隆本身表现出髓细胞和淋巴细胞的两种表型。Ph~1阳性慢粒白血病有这种表现已被充分肯定,目前,急性白血病时,似乎很可能发生同样的现象。双相白血病应与混合表型(一种白血病细胞有多细胞系的表型特征)的白血病相鉴别。双相白血病的鉴定,不仅需要形态学的观察,还要作细胞化学、生物化学和免疫学标志的研究。标志物的特异性必须是已知的。如同种异基因(Ia-like)抗原的早期研究认为是 Leukemia cells also display the characteristics of myeloid cells and lymphocyte characteristics of leukemia, called Biphenotypic Leukaemia. Its meaning is that a leukemia clone itself shows two phenotypes of myeloid cells and lymphocytes. This behavior of Ph~1 positive chronic myeloid leukemia has been fully confirmed. At present, it seems that the same phenomenon may occur in acute leukemia. Biphasic leukemia should be distinguished from leukemia with a mixed phenotype, a phenotypic feature of leukemia cells with multiple cell lines. The identification of biphasic leukemia requires not only morphological observations, but also cytochemical, biochemical, and immunological markers. The specificity of the marker must be known. Early studies like Ia-like antigens were thought to be