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目的探讨子宫内膜异位症患者实施腹腔镜术后应用戈舍瑞林(诺雷德)预防复发的效果。方法选择2009年1月至2010年6月在我院住院行腹腔镜手术的子宫内膜异位症患者120例作为观察对象,按术后治疗方法不同将患者分为观察组和对照组,每组60例。观察组术后采用戈舍瑞林治疗,治疗时间6个月,对照组采用常规治疗。随访2年,对比疾病复发情况、妊娠率、不良反应发生率。结果观察组子宫内膜异位症复发率为20.0%,对照组复发率为48.3%,两组比较差异有统计学意义;观察组不良反应发生率为63.3%,对照组为3.3%,两组不良反应发生率差异有统计学意义;观察组术后2年妊娠率为88.3%,对照组术后2年妊娠率为43.3%,两组术后妊娠率差异有统计学意义。结论对子宫内膜异位症患者腹腔镜手术后给予戈舍瑞林,能降低术后复发率,提高妊娠率。
Objective To investigate the effect of Goserelin (Norelide) on prevention of recurrence after endoscopic surgery in patients with endometriosis. Methods A total of 120 patients with endometriosis undergoing laparoscopic surgery in our hospital from January 2009 to June 2010 were selected as observation subjects and divided into observation group and control group according to different postoperative treatment methods Group of 60 cases. The observation group was treated with goserelin, the treatment time was 6 months, and the control group was treated by conventional therapy. Followed up for 2 years, compared the incidence of disease recurrence, pregnancy rate, the incidence of adverse reactions. Results The recurrence rate of endometriosis was 20.0% in the observation group and 48.3% in the control group, with significant difference between the two groups; the incidence of adverse reactions in the observation group was 63.3% and in the control group was 3.3% The incidence of adverse reactions was significantly different; observation group 2 years after pregnancy rate was 88.3%, control group 2 years after pregnancy rate was 43.3%, postoperative pregnancy rate difference between the two groups was statistically significant. Conclusion Goserelin is given after laparoscopic surgery in patients with endometriosis, which can reduce the recurrence rate and improve the pregnancy rate.