对不同接振时间的 6 4名煤矿掘进工进行了血浆内皮素、一氧化氮浓度的测定。结果表明 ,各个接振时间段内皮素浓度均高于对照组 ,并随接振时间的延长增高更明显 (P <0 0 5 ,P <0 0 1)。在接振时间≤ 5 0 0 0h时 ,一氧化氮浓度高于对照组 ,但无统计学意义 (P >0 0 5 ) ;接振时间 >5 0 0 0h ,一氧化氮浓度低于对照组 ,且随接振时间延长 ,降低更明显 (P <0 0 5 ,P <0 0 1)。表明手传振动可致煤矿掘进工血浆内皮素浓度的升高及一氧化氮浓度的下降 ,这种改变可能与振动性血管损伤有一定联系 Sixty four coal miners with different pick-up times were tested for plasma endothelin and nitric oxide concentrations. The results showed that the concentration of endothelin was higher than that of the control group at each time of shaking-up, and the concentration of endothelin increased more obviously with the prolongation of shaking time (P <0.05, P <0.01). The nitric oxide concentration was higher than that of the control group at the time of 50000h, but no statistical significance (P> 0.05). When the vibration time was> 500h, the concentration of nitric oxide was lower than that of the control group , And the decrease was more obvious with the extension of vibration duration (P <0.05, P <0.01). The results showed that the increase of plasma endothelin concentration and the decrease of nitric oxide concentration could be caused by hand vibration, which may be related to vasomotion