冠心病患者往往血小板聚集活性增高,为降低血小板聚集活性,常使用乙酰水杨酸(ASA),此药在血中迅速水解,通过使血小板环氧化酶乙酰化,阻滞花生四烯酸转化为血栓烷A_2(TXA_2)。作者用水溶性ASA静注治疗心绞痛,研究其对血小板聚集的影响。病人和方法进行性心绞痛27例(男22例,女5例;平均年龄61.7±4.8岁)。近2～3周发作频繁或加重,用硝酸盐、β-阻滞剂或钙拮抗剂抗心绞痛效果不明显。用德国Bayer Patients with coronary heart disease tend to have increased platelet aggregation activity. In order to reduce platelet aggregation activity, acetylsalicylic acid (ASA) is often used. This drug hydrolyzes rapidly in the blood and blocks arachidonic acid conversion by acetylating platelet cyclooxygenase Thromboxane A_2 (TXA_2). The authors used water-soluble ASA intravenous treatment of angina pectoris study its impact on platelet aggregation. Patients and Methods 27 cases of angina (22 males and 5 females; mean age 61.7 ± 4.8 years). Almost 2 to 3 weeks episodes of frequent or aggravated, with nitrates, β-blockers or calcium antagonist anti-angina effect is not obvious. With German Bayer