目的调查鼻咽癌患者放疗后晚期并发症的发病情况,分析引起各并发症的相关因素。方法采用问卷调查的方法调查自2006年6月至2006年12月间接受根治性放疗的96例鼻咽癌患者放疗后的晚期并发症,观察其发生率、评价其严重程度,分析各并发症的相关影响因素。结果口干、听力下降和放射性龋齿2级以上的发生率分别为48.96%、23.96%和20.83%。原发灶剂量与张口困难、听力下降有明显的相关性(P=0.012,0.007)。应用不规则整体挡铅技术对放射性龋齿的影响具有显著性(P=0.001)。颈部局部肿块的剂量是颈部皮下纤维化的明显影响因素(P=0.000)。结论鼻咽癌放疗后的晚期并发症的发病率较高,明显影响患者生存质量。 Objective To investigate the incidence of postoperative complications in patients with nasopharyngeal carcinoma after radiotherapy and to analyze the related factors that cause each complication. Methods A total of 96 nasopharyngeal carcinoma patients undergoing radical radiotherapy from June 2006 to December 2006 were enrolled in this study. The late complications after radiotherapy were observed. The incidence, the severity and the complications were analyzed. Related factors. Results The incidences of dry mouth, hearing loss and radioactive dental caries with grade 2 or above were 48.96%, 23.96% and 20.83% respectively. Primary dose and port opening difficulties, hearing loss was significantly correlated (P = 0.012,0.007). The application of irregular overall blockade of lead on the impact of radioactive dental caries was significant (P = 0.001). The dose of local neck mass was a significant factor in the subcutaneous fibrosis of the neck (P = 0.000). Conclusion The incidence of late complications after radiotherapy of nasopharyngeal carcinoma is high, which obviously affects the quality of life of patients.