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目的探讨动脉硬化性脑梗死(ACI)患者的血清甘油三酯浓度与血浆PAI-1活性的关系。方法测定了91例ACI患者和40例健康老年人的血脂浓度和血浆t-PA和PAI-1活性;采用常规方法测定血脂和脂蛋白;采用发色底物法测定血浆t-PA和PAI-1活性。结果ACI患者急性期和恢复期的血浆t-PA活性分别为(0.26±0.14)和(0.21±0.11)kIU/L,显著低于健康组(P<0.01),血浆PAI-1活性分别为(0.90±0.25)和(0.98±0.12)kAU/L,显著高于健康组(P<0.01);急性期和恢复期的血清TG、CHO、LDL、ApoB和Lp(a)的浓度显著高于健康组(P<0.05～0.01),血清ApoA、HDL显著低于健康组(P<0.05～0.01)。ACI患者急性期和恢复期的血浆PAI-1活性与血清TG、LDL、ApoB、Lp(a)浓度正相关,血浆t-PA活性与血脂各项参数不相关。结论ACI患者增高的血清TG浓度提高血浆PAI-1活性,高甘油三酯血症和血浆PAI-1活性增高为ACI的重要危险因素。
Objective To investigate the relationship between serum triglyceride concentration and plasma PAI-1 activity in patients with arteriosclerotic cerebral infarction (ACI). Methods Serum lipids and plasma t-PA and PAI-1 activities were measured in 91 patients with ACI and 40 healthy controls. Serum lipids and lipoproteins were measured by routine methods. The levels of plasma t-PA and PAI- 1 activity. Results The plasma levels of t-PA in acute and convalescent ACI patients were (0.26 ± 0.14) and (0.21 ± 0.11) kIU / L, respectively, significantly lower than those in healthy controls (P <0.01) 0.90 ± 0.25) and (0.98 ± 0.12) kAU / L respectively, which were significantly higher than those in healthy group (P <0.01). The levels of serum TG, CHO, LDL, ApoB and Lp (a) in acute and convalescent periods were significantly higher than those in healthy Group (P <0.05 ~ 0.01), serum ApoA, HDL was significantly lower than the healthy group (P <0.05 ~ 0.01). Plasma PAI-1 activity in acute and convalescent ACI patients was positively correlated with serum TG, LDL, ApoB and Lp (a) concentrations. The activity of plasma t-PA was not related to the parameters of blood lipids. Conclusions Increased serum TG concentration in patients with ACI can increase plasma PAI-1 activity, hypertriglyceridemia and plasma PAI-1 activity as important risk factors for ACI.