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目的:观察复方丹参滴丸对原发性肝癌(PLC)肝动脉化疗栓塞术(TACE)后疗效及细胞免疫功能的影响。方法:90例PLC患者随机分为对照组和观察组各45例,对照组患者行TACE术,同时口服阿德福韦酯片10 mg,qd,观察组患者在对照组基础上加用复方丹参滴丸270 mg,po,tid,疗程均为3个月。比较两组患者临床疗效、肝纤维化指标、免疫功能(T淋巴细胞亚群)和药品不良反应。结果:观察组临床缓解率为66.7%,明显高于对照组(P<0.05)。两组治疗后透明质酸(HA)、层黏蛋白(LN)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳc)、CD8+降低,CD3+、CD4+及CD4+/CD8+升高(P<0.05),且对照组改变幅度大于观察组(P<0.05)。两组药品不良反应发生率相近(P>0.05)。结论:复方丹参滴丸联合阿德福韦酯可明显减轻TACE所致PLC患者的免疫功能下降和纤维化,提高疗效。
Objective: To observe the effect of Fufang Danshen Diwan on curative effect and cellular immune function after transcatheter arterial chemoembolization (TACE) in primary hepatocellular carcinoma (PLC). Methods: Ninety PLC patients were randomly divided into control group and observation group, 45 cases in each group. Patients in control group were treated with TACE and oral adefovir dipivoxil 10 mg qd. The patients in observation group were treated with Fufang Danshen Dripping pills 270 mg, po, tid, treatment were 3 months. Clinical efficacy, liver fibrosis indicators, immune function (T lymphocyte subsets) and adverse drug reactions were compared between the two groups. Results: The clinical remission rate in observation group was 66.7%, which was significantly higher than that in control group (P <0.05). Hyaluronic acid (HA), laminin (LN), type Ⅲ procollagen (Ⅲ), type Ⅳ collagen (Ⅳc), CD8 + and CD3 +, CD4 + and CD4 + / CD8 + , And the control group changed more than the observation group (P <0.05). Two groups of drug adverse reactions were similar (P> 0.05). Conclusion: Compound Danshen dripping pills combined with adefovir dipivoxil can obviously reduce the decline of immune function and fibrosis in PLC patients caused by TACE, and improve the curative effect.