热休克蛋白(HSP)肿瘤疫苗研究是国内外的研究热点之一,近几年取得较大进展。新型HSP的发现与研究、特定HSP新功能的应用、包涵体蛋白复性新方法的运用以及DNA疫苗的尝试等为HSP肿瘤疫苗研究开辟了新空间。一些HSP肽复合物肿瘤疫苗陆续进入临床试验,有的已进入Ⅲ期试验,结果令人鼓舞。 Research on heat shock protein (HSP) tumor vaccine is one of the hot spots both at home and abroad, and great progress has been made in recent years. The discovery and research of novel HSPs, the application of specific HSPs, the application of new methods of inclusion body protein renaturation and the attempt of DNA vaccines have opened up a new space for the study of HSP tumor vaccine. Some HSP peptide complex tumor vaccines one after another into clinical trials, and some have entered the Phase III trial, the results are encouraging.