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目的:探讨中、晚期恶性肿瘤患者医院内细菌L型的感染情况及防治措施。方法:对临床分离的369例中、晚期恶性肿瘤L型培养及药敏试验。结果:细菌型培养阳性者191例,阳性率51.9%;细菌L型阳性者69例,阳性率18.7%;单纯L型阳性者39例,阳性率10.6%。两种菌型感染菌种均以G-杆菌为主,细菌型G-杆菌占75.9%,细菌L型占79.8%。其药敏试验细菌型部分菌种对青霉素和头孢菌素敏感,而L型对其不敏感。结论:中、晚期恶性肿瘤口才并发医院内细菌感染,其细菌L型也常常存在,检验人员在做常规细菌培养的同时,应重视L型细菌的检测。临床医生在治疗中、晚期恶性肿瘤患者时,一定要合理应用抗生素,避免预防性使用抗生素,要防止医院内感染、积极控制感染,以防感染细菌型变成L型细菌产生耐药性。
Objective: To investigate the prevalence and prevention and treatment of bacterial L-forms in patients with advanced and advanced malignant tumors. Methods: The clinical culture of 369 cases of advanced malignant tumor L-type culture and drug sensitivity test. Results: There were 191 cases positive for bacterial culture, the positive rate was 51.9%. 69 cases were positive for bacterial L type, the positive rate was 18.7%. There were 39 cases with pure L type positive rate, the positive rate was 10.6%. The two strains of bacterial infection are G-bacteria-based bacteria accounted for 75.9% of G-bacteria, L bacteria accounted for 79.8%. The drug-susceptibility test of bacterial-type strains of penicillin and cephalosporin-sensitive, while the L-type is not sensitive to it. Conclusion: The middle and late stage malignant neoplasms complicated with nosocomial bacterial infections often contain L-forms of bacteria. While testing routine bacterial cultures, laboratory personnel should pay attention to the detection of L-type bacteria. Clinicians in the treatment of advanced cancer patients, we must rational use of antibiotics to prevent the prophylactic use of antibiotics, to prevent nosocomial infections, and actively control the infection, to prevent bacterial infection into L-type bacteria resistance.