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在临床治疗中,抗酸药不仅用来治疗胃病,而且常常用来克服一些药物对胃肠道的副作用。据近来报道,抗酸药是一类对药物吸收过程易产生相互作用的药物。由于其吸收作用或通过形成络合物,改变胃内pH值和胃排空速率而影响许多药物的胃肠道吸收,从而使其它药物降效,甚至失效,故应值得我们重视,本文就常用药物与抗酸药联用的相互作用简述如下。一、弱酸或弱碱性药物与抗酸药联用抗酸药由于改变胃肠道内的pH值,而影响弱碱性和弱酸性有机药物的非离子化浓度,从而影响其吸收。弱碱性药物如:喹啉、喹尼丁、麻黄碱、安替比林、苯丙胺等,在酸性环
In clinical treatment, antacids are not only used to treat stomach problems, but also often used to overcome the side effects of some drugs on the gastrointestinal tract. It has recently been reported that antacids are a class of drugs that are likely to interact with the drug absorption process. Due to its absorption or through the formation of complexes, changing the gastric pH and gastric emptying rate of many drugs affect the gastrointestinal absorption, so that other drugs reduce efficiency, or even failure, it deserves our attention, this article is commonly used The interaction of drugs and antacids is summarized as follows. First, the weak acid or weak alkaline drugs and antacids combined with antacids due to changing the pH value of the gastrointestinal tract, and affect the weakly acidic and slightly acidic organic non-ionized drug concentration, thus affecting its absorption. Weak alkaline drugs such as: quinoline, quinidine, ephedrine, antipyrine, amphetamine, etc., in the acidic ring