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目的:分析抗癫痫药物临床使用时诱导儿童过敏反应发生的特点和规律。方法:报告7例抗癫痫药物诱导儿童过敏反应及参考国内文献。结果:芳香族与非芳香族抗癫痫药物均可引起过敏反应,以芳香族抗癫痫药物为主,大多发生在服药后的两周之内,严重时可发生高敏综合征,糖皮质激素是其治疗的首选药物之一。结论:抗癫痫药物可以诱导儿童过敏反应,在儿科应用时应严格掌握药物说明书,并交代家长注意观察不良反应,保障儿童用药安全。
Objective: To analyze the characteristics and regularities of the induction of allergic reactions in children when the antiepileptic drugs are used clinically. Methods: Seven cases of antiepileptic drugs were reported to induce allergic reaction in children and reference to domestic literature. Results: Aromatic and non-aromatic anti-epileptic drugs can cause anaphylactic reactions, mainly aromatic antiepileptic drugs, mostly occurred within two weeks after taking the drug. In severe cases, hypersensitivity syndrome may occur. Glucocorticoid is the One of the drug of choice for treatment. Conclusion: Antiepileptic drugs can induce allergic reactions in children. In pediatric applications, the manuals of drugs should be strictly controlled and parents should pay attention to observe the adverse reactions to ensure the safety of children.