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目的探讨上皮样滋养细胞肿瘤(ETT)的临床病理特点及预后相关的因素。方法回顾性分析北京协和医院2002年1月至2010年8月间9例ETT的临床病理特点、治疗和预后。结果 7例发生转移(7/9,77.8%),4例为多脏器转移。7例不良结局者均存在子宫多发病灶,侵及子宫全层,累及浆膜,伴大片坏死,6例子宫增大≥如孕8周,2例为低分化。所有患者均给予手术联合化疗的综合治疗,初治完全缓解(CR)5例,部分缓解(PR)1例,病情进展死亡3例(3/9,33.3%);随诊2～103个月,其中3例CR后复发(3/9,33.3%),复发后经治疗再次CR。结论 ETT恶性程度比胎盘部位滋养细胞肿瘤高。提高ETT早期诊断率,早期识别不良预后因素,对不良预后者尽早给予多手段的综合治疗,以改善患者预后。
Objective To investigate the clinicopathological features and prognostic factors of epithelial-like trophoblastic tumor (ETT). Methods A retrospective analysis of Beijing Union Medical College Hospital from January 2002 to August 2010 9 cases of ETT clinicopathological features, treatment and prognosis. Results Seven cases had metastasis (7 / 9,77.8%) and four cases had multiple organ metastasis. Seven cases of unfavorable outcomes were multiple lesions of the uterus, invasion and uterine full-thickness, involving the serosa, with large necrosis, 6 cases of uterine enlargement such as 8 weeks pregnant, 2 cases of poorly differentiated. All patients were treated with combined chemotherapy and chemotherapy. There were 5 cases of complete remission (CR), 1 case of partial remission (PR), and 3 cases of disease progression (3 / 9,33.3%). The patients were followed up for 2 to 103 months , Of which 3 cases relapsed after CR (3/9, 33.3%). After treatment, CR again after treatment. Conclusions ETT is more malignant than trophoblastic tumor at placenta. Improve the early diagnosis of ETT, early identification of adverse prognostic factors, as early as possible to poor prognosis given multiple means of comprehensive treatment to improve patient prognosis.