论文部分内容阅读
早期对胃泌素瘤病人的研究表明,这是一种难治的、多发性、侵袭性的复发性消化性溃疡,与一般有广泛转移的胰岛细胞瘤有关.现已认识到,高酸的大量分泌及其并发症系循环中高浓度的胃泌素所致,这些胃泌素由胰腺内分泌瘤产生.本综合征首先由Zollinger和Ellison描述.其发病率在丹麦为每年每百万人中有一人.美国每年35万例新发病的消化性溃疡中,胃泌素瘤所占比例虽小,但有意义.胃泌素瘤至少60%为恶性.手术时50%以上病人已有肝转移.而且,50%以上病人胰腺内可见多发性病变或转移灶.术后,有50%的病人复发.因此
Early studies of patients with gastrinoma showed that it was a refractory, multiple, invasive, recurrent peptic ulcer associated with widespread metastases of islet cell tumors. It has now been recognized that high-acid A large number of secretions and their complications are caused by circulating high levels of gastrin, which are produced by pancreatic endocrine tumors. This syndrome was first described by Zollinger and Ellison. The incidence rate in Denmark is one million per year. One person. In the United States, 350,000 cases of newly-occurring peptic ulcers, the proportion of gastrinoma is small, but meaningful. Gastrinoma at least 60% of malignant. More than 50% of patients have liver metastasis during surgery. Moreover, more than 50% of patients have multiple lesions or metastases in the pancreas. After surgery, 50% of patients relapse.