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目前,认为可以预防缺血心肌损害的手段有2种机制,一是增强缺血心肌的耐性;二是增加缺血部位心肌的灌流量。本文介绍应用硝苯吡啶通过这2种作用机制,保护缺血心肌。一、硝苯吡啶对整个心肌缺血的作用作者为了证明硝苯吡啶对缺血心肌具有直接作用的效果,通过兔的离体心脏和利用人工心肺后,造成整个缺血的狗心脏进行了各种试验。其结果提示硝苯吡啶对心脏的保护作用,是与冠状动脉血流量和心脏负荷无关的直接作用。因此认为该药可能是由于阻止了在缺血低氧状态下的细胞内,不适量的钙蓄积的缘
At present, there are two mechanisms that can be used to prevent ischemic myocardial damage: one is to enhance the tolerance of ischemic myocardium; the other is to increase the perfusion of ischemic myocardium. This article describes the application of nifedipine through these two mechanisms of action to protect ischemic myocardium. First, the effect of nifedipine on the whole myocardial ischemia Authors in order to prove the effect of nifedipine on ischemic myocardium has a direct effect, through the rabbit’s isolated heart and the use of artificial heart and lung, causing the entire ischemic dog heart were Tests. The results suggest that nifedipine has a protective effect on the heart that is directly related to coronary blood flow and heart load. Therefore, it is considered that the drug may be due to the prevention of ischemia in the hypoxic state of the cell, the amount of improper storage of calcium edge