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目的观察曲美他嗪和美托洛尔联合应用治疗慢性心力衰竭(CHF)的临床疗效。方法120例CHF患者随机分为治疗组和对照组各60例,两组均给予强心、利尿、血管紧张素转换酶抑制剂治疗,治疗组加服曲美他嗪和美托洛尔,3个月后随访观察。结果两组CHF患者治疗后心功能均得到不同程度的改善,治疗组总有效率为91.7%,对照组总有效率为70.0%,二者有显著性差异(P<0.01)。结论曲美他嗪和美托洛尔治疗CHF安全有效。
Objective To observe the clinical efficacy of trimetazidine combined with metoprolol in the treatment of chronic heart failure (CHF). Methods 120 patients with CHF were randomly divided into treatment group and control group of 60 cases, both groups were given cardiac, diuretic, angiotensin converting enzyme inhibitor treatment, the treatment group with trimetazidine and metoprolol, 3 Follow-up observation after month. Results The heart function of CHF patients in both groups improved to some extent after treatment. The total effective rate was 91.7% in the treatment group and 70.0% in the control group, with significant difference (P <0.01). Conclusion Trimetazidine and metoprolol are safe and effective in the treatment of CHF.