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目的 :观察癫持续状态 (SE)后小鼠海马活化素A、抑制素A蛋白及活化素ⅡA受体mRNA表达的变化。方法 :采用匹鲁卡品诱导的SE小鼠模型 ,分别应用Westernblot与RT PCR观察SE后活化素A与抑制素A蛋白及活化素ⅡA受体mRNA表达的动态变化。结果 :①活化素A蛋白于SE后 3h开始增高 ,6h显著增高 ,2 4h至高峰 ,48h仍维持在较高水平 ;而未成SE的小鼠活化素A表达无明显变化。②抑制素A蛋白SE后无明显增加 ,同正常小鼠及未成SE的小鼠比较无显著差异。③活化素ⅡA受体mRNA在SE后表达无明显变化。结论 :SE后海马活化素A、抑制素A蛋白及活化素ⅡA受体mRNA表达存在差异性 ;活化素A可能对性脑损伤的保护与修复具有重要作用。
Objective: To observe the changes of mRNA expression of activin A, inhibin A and activin Ⅱ A in hippocampus of rats after epileptic seizure (SE). Methods: The SE mouse model induced by pilocarpine was used to observe the dynamic changes of activin A and inhibin A protein and activin Ⅱ A receptor mRNA expression by Western blot and RT PCR respectively. Results: (1) Activin A protein began to increase at 3h after SE, increased significantly at 6h, peaked at 24h, remained at a relatively high level at 48h; while there was no significant change in activin A expression in mice without SE. ② There was no significant increase of inhibin A protein after SE, no significant difference compared with normal mice and non-SE mice. ③ Activin Ⅱ A receptor mRNA expression in the SE after no significant change. Conclusion: The expression of activin A, inhibin protein A and activin Ⅱ A receptor mRNA in hippocampus after SE are different. Activin A may play an important role in the protection and repair of brainstem injury.