论文部分内容阅读
目的探讨结直肠癌患者术后抗菌药物使用情况与手术切口感染的关系。方法回顾性分析了2003年2月-2010年12月收治的547例结直肠癌患者病例资料,按手术切口感染情况分为A组:切口感染组105例,B组:切口无感染组442例,比较2组患者抗菌药物使用时间及联合用药情况,再将所有患者按抗菌药物使用时间分为:>72h组和<72h组,比较2组切口感染率。结果 A组术后用药时间高于B组,差异有统计学意义(P<0.05);2组抗菌药物用药方案差异无统计学意义,抗菌药物使用时间>48h组的切口感染率,高于抗菌药物使用时间<48h组,但差异无统计学意义。结论结直肠癌患者手术切口感染,是一个多因素相互作用的过程,增加抗菌药物的使用时间和多联合用药并不能使切口感染率下降,外科医师应该增强合理用药的意识。
Objective To investigate the relationship between the use of antibacterials and surgical incision infection in patients with colorectal cancer after operation. Methods The data of 547 patients with colorectal cancer admitted from February 2003 to December 2010 were retrospectively analyzed. According to the surgical incision infection, the patients were divided into group A (105 cases), group B (442 cases) The duration of antimicrobial use and the combination therapy were compared between the two groups. All patients were divided into two groups according to their antibacterial time:> 72h group and <72h group. Incision infection rate was compared between the two groups. Results The duration of postoperative medication in group A was significantly higher than that in group B (P <0.05). There was no significant difference in the dosage of antibacterials between the two groups Drug use time <48h group, but the difference was not statistically significant. Conclusion The surgical incision infection in patients with colorectal cancer is a multifactorial interaction process. Increasing antibiotic usage time and multiple combination therapy can not reduce incision infection rate, and surgeons should enhance awareness of rational drug use.