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目的:探讨胎盘转化生长因子-β(TGF-β)三种亚型及其受体的表达与妊娠期肝内胆汁淤积症(ICP)的关系。方法:用免疫组织化学染色技术(SP法)检测ICP患者和正常妊娠胎盘组织中TGF-β1、2、3三种亚型和两种功能型受体(TGF-βRⅠ和TGF-βRⅡ)的表达水平。结果:ICP患者胎盘绒毛TGF-β2表达的平均面积、染色强度和IOD值均明显小于正常妊娠组(P“,”Objective:To explore the relationship between expressions of three transforming growth factor-β(TGF-β) subtypes and the receptors and intrahepatic cholestasis of pregnancy(ICP).Methods:Immunohistochemical SP method was used to detect the expression levels of TGF-β1,TGF-β2,TGF-β3,TGF-β RⅠ,and TGF-β RⅡ in placental tissues of ICP patients and normal pregnant women.Results:The mean area,staining intensity,and IOD value of TGF-β2 in placental villi of ICP group were statistically significantly lower than those in normal pregnancy group(P<0.01),there was a negative correlation between IOD value and maternal blood total bile acid(TBA)(γ=-0.824,P<0.01);the area and IOD value of TGF-β RⅡ in ICP group were statistically significantly higher than those in normal pregnancy group(P<0.01,P<0.05);but there was no statistically significant difference in TGF-β1,TGF-β3,and TGF-β RⅠbetween the two groups.Conclusion:The cause of imbalance of immune tolerance-immune rejection in ICP patients may be correlated with abnormal expressions of TGF-β2/TGF-β RⅡ.