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目的分析人乳头瘤病毒(Human papilloma virus,HPV)在非妊娠妇女和妊娠妇女中感染及基因亚型分布的情况。方法采用PCR反向点杂交法对该院2013年2月-2014年12月就诊的700名非育龄期妇女(A组)和785名妊娠期妇女(B组)进行基因分型,并统计HPV感染率。结果非妊娠期妇女的HPV感染率为22.57%(158/700),妊娠期妇女的HPV感染率为11.46%(90/785),两组之间差异有统计学意义(P<0.001),但两组间混合感染率的差异无统计学意义(P>0.05)。非妊娠期组,小于30岁(10.58%)和大于40岁(22.20%)这两组妇女HPV感染率高于31~40岁组(15.03%)妇女,差异有统计学意义(P<0.05)。最常见的HPV亚型在A组和B组中分别为67.72%(107/158)和60.00%(54/90),A组中HPV16、58、18、52亚型的感染率明显高于B组(P<0.05),两组的HPV33和HPV6亚型感染率差异无统计学意义(P>0.05)。结论非妊娠期妇女HPV感染率高于妊娠期妇女,感染HPV主要亚型相同。
Objective To analyze the distribution and distribution of human papilloma virus (HPV) in non-pregnant and pregnant women. Methods 700 non-infertile women (group A) and 785 pregnant women (group B) were enrolled in this hospital from February 2013 to December 2014 by PCR reverse dot blot hybridization. The genotypes of HPV Infection rate. Results The prevalence of HPV infection in non-pregnant women was 22.57% (158/700). The prevalence of HPV infection in pregnant women was 11.46% (90/785). There was a significant difference between the two groups (P <0.001) There was no significant difference in the rate of mixed infection between the two groups (P> 0.05). In non-pregnant group, HPV infection rate of women younger than 30 years old (10.58%) and older than 40 years old (22.20%) was higher than that of women aged 31-40 years (15.03%), the difference was statistically significant (P0.05) . The most common HPV subtypes were 67.72% (107/158) and 60.00% (54/90) in group A and group B. The infection rates of HPV16, 58, 18 and 52 in group A were significantly higher than those in group B Group (P <0.05). There was no significant difference in the infection rates of HPV33 and HPV6 among the two groups (P> 0.05). Conclusion The HPV infection rate of non-pregnant women is higher than that of pregnant women, and the main subtypes of HPV infection are the same.