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目的建立测定大鼠血浆中右旋布洛芬的LC-MS/MS方法,并用于研究大鼠口服右旋布洛芬和右旋布洛芬精氨酸盐后右旋布洛芬的药动学。方法大鼠单次口服右旋布洛芬和右旋布洛芬精氨酸盐,于给药后不同时间采集血样,血浆样本经沉淀蛋白后,以吲哚美辛为内标,LC-MS/MS测定血浆中右旋布洛芬的浓度。结果大鼠口服右旋布洛芬和右旋布洛芬精氨酸盐后右旋布洛芬均迅速吸收;大鼠口服右旋布洛芬精氨酸盐后血浆中右旋布洛芬的AUC,较其口服等剂量右旋布洛芬后的AUC明显增大。结论右旋布洛芬和精氨酸成盐后其生物利用度增加。
Objective To establish a LC-MS / MS method for determination of dexibuprofen in rat plasma and to study the pharmacokinetics of dexibuprofen after oral administration of dexibuprofen and dexibuprofen arginine in rats learn. Methods Rat single oral administration of dexibuprofen and dexibuprofen arginine salt, blood samples were collected at different times after administration. The plasma samples were precipitated with indomethacin and LC-MS / MS determination of plasma concentration of dexibuprofen. Results After oral administration of dexibupramine and dexibuprofen arginine, rats were rapidly absorbed with dexibuprofen. After oral administration of dexibupramorph arginine, dexibuprofen AUC, than its oral dose of dexibuprofen AUC significantly increased. Conclusion The bioavailability of dexibuprofen and arginine after salt formation increased.