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近年来,文献报道有些AML病人的细胞可以产生多种造血生长因子和白细胞介素.如:GM-CSF、G-CSF、M-CSF、和IL-1.本文首次报道AML白血病细胞也可产生IL-6.用IL-6依赖株——小鼠杂交瘤细胞系B9作靶细胞,以~3H-TdR掺入率为指标测定白血病细胞条件培养液中IL-6的含量.测定30例AML病人(M1七例,M2八例,M4九例,M5六例).结果是:6/9的M4病人和6/6的M5病人大量分泌IL-6,而M1和M2病人几乎不分泌或仅少量分泌.两组相比有显著差异(P<0.005).说明:白血病细胞分泌IL-6的能力与
In recent years, it has been reported in the literature that some cells of AML patients can produce multiple hematopoietic growth factors and interleukins, such as GM-CSF, G-CSF, M-CSF, and IL-1. This article first reported that AML leukemia cells can also be produced. IL-6. The IL-6-dependent strain, a mouse hybridoma cell line B9, was used as a target cell, and the content of IL-6 in the leukemia cell conditioned medium was measured by the incorporation rate of ~3H-TdR. 30 cases of AML were determined. Patients (7 cases in M1, 8 cases in M2, 9 cases in M4, and 6 cases in M5). The result was that 6/9 of M4 patients and 6/6 of M5 patients secreted IL-6 in large amounts, while M1 and M2 patients hardly secreted or Only a small amount was secreted. There was a significant difference between the two groups (P<0.005). Description: The ability of leukemia cells to secrete IL-6