There are prominent nonlinear characteristics that we hope for the semiconductor nano-clusters doped fiber. Refractive index of fiber core can be effectively changed by adulteration. This technology can provide a new method for developing photons components. Because the semiconductor nano-cluster has quantum characteristics, Based on first-order perturba- tion theory and classical theory of fiber, we deduced refractive index expressions of fiber core, which was semiconductor nano-cluster doped fiber. Finally, third-order nonlinear coefficient equation was gained. Using this equation, we calculated SMF-28 fiber nonlinear coefficient. The equation shows that new third-order coefficient was greater. There are prominent nonlinear characteristics that we hope for the semiconductor nano-clusters doped fiber. Due to the semiconductor nano-cluster has quantum characteristics , Based on first-order perturba- tion theory and classical theory of fiber, we deduced refractive index expressions of fiber core, which was semiconductor nano-cluster doped fiber. Finally, third-order nonlinear coefficient equation was gained. calculated SMF-28 fiber nonlinear coefficient. The equation shows that new third-order coefficient was greater.