本文介绍了用亲水性甲基丙烯酸羟乙酯(HEMA)与甲基丙烯酸甲酯(MA)共聚物的恒释四环素膜的体内外释药情况。实验结果表明,该膜在体外能在四个月以上的时间内以恒定的速率释放四环素;而体内释药与体外一样,药物浓度在2～4天内达到平衡,14天内维持平衡。传统的给药方法,在开始给药时,往往药物释放量过多,以致病人有中毒的危险;而随着药物的分解代谢,血药浓度又逐渐下降到应有的水平以下,使病情不能控制。为此,近年来除了研制新药外,也开始研究改良用药的方法,以充分发挥药物的作用,取得更好疗效。其中特别是改变间歇用药的方法,使药 This article describes the in vitro and in vivo release of tetracycline membranes in vivo using hydrophilic copolymers of HEMA and MA. The experimental results show that the membrane can release tetracycline at a constant rate for more than four months in vitro. In vivo drug release is the same as in vitro, and the drug concentration is balanced within 2-4 days and maintained within 14 days. The traditional method of administration, at the beginning of administration, often drug release is too much, so that patients are at risk of poisoning; and with the catabolism of drugs, blood drug concentration and gradually dropped below the level that should be, so that the disease can not control. To this end, in addition to the development of new drugs in recent years, but also began to study ways to improve the medication in order to give full play to the role of drugs to achieve better efficacy. Among them, in particular, the method of changing intermittent medication is used to make medicine