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目的：探讨粉防己碱抗豚鼠再灌注早期心室颤动作用及其机制。方法：利用心肌缺血再灌注损伤模型，研究粉防己碱对再灌注早期心脏去甲肾上腺素（ＮＡ）释放及心室颤动发生的影响。结果：①粉防己碱使心脏流出液中ＮＡ含量从每克心脏组织３．７２±０．９６ｐｍｏｌ／ｍｉｎ减低为０．７８±０．３６ｐｍｏｌ／ｍｉｎ（ｎ＝７，Ｐ＜０．００１）。②粉防己碱可明显降低再灌注早期心室颤动的发生（Ｐ＜０．０５）。结论：粉防己碱可明显减少再灌注早期心交感神经递质ＮＡ的释放，同时可明显减少心室颤动发生。该减少再灌注早期心交感神经递质ＮＡ释放的作用应是抗再灌注性心律失常—心室颤动作用机制之一。
Objective: To investigate the effect of tetrandrine on early ventricular fibrillation in guinea pigs and its mechanism. METHODS: The effects of tetrandrine on the release of norepinephrine (NA) and the occurrence of ventricular fibrillation in the early stage of reperfusion were studied using myocardial ischemia-reperfusion injury model. Results: 1 Tetrandrine reduced the NA content in the cardiac effluent from 3.72±0.96 pmol/min per gram of cardiac tissue to 0.78±0.36 pmol/min (n=7, P<0.001). 2 Tetrandrine can significantly reduce the occurrence of ventricular fibrillation at the early stage of reperfusion (P<0.05). Conclusion: Tetrandrine can significantly reduce the release of cardiac sympathetic neurotransmitter NA in the early stage of reperfusion and significantly reduce the occurrence of ventricular fibrillation. The role of reducing the release of cardiac sympathetic neurotransmitter NA during reperfusion should be one of anti-reperfusion arrhythmia, the mechanism of action of ventricular fibrillation.