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胰高血糖素样肽-2(GLP-2)是由一种肠内分泌L细胞分泌,特异性促进肠黏膜生长与损伤后修复的多肽类激素。GLP-2通过G蛋白耦联受体的转导实现其生物学作用,通过刺激隐窝细胞增生及抑制细胞凋亡显著地增加了肠黏膜上皮的表面积,促进肠道营养吸收,增强肠屏障功能,维护肠黏膜的连续性和完整性。GLP-2的上述特性,提示其对人类疾病尤其是肠道疾病具有治疗潜能。本文综述了GLP-2的生物学特性及其对肠道黏膜的保护作用。
Glucagon-like peptide-2 (GLP-2) is a peptide hormone that is secreted by an enteroendocrine L-cell that specifically promotes intestinal mucosal growth and repair after injury. GLP-2 through the G protein-coupled receptor transduction to achieve its biological effects, by stimulating crypt cell proliferation and inhibition of apoptosis significantly increased intestinal mucosal epithelial surface area, promote intestinal nutrient absorption and enhance intestinal barrier function , To maintain the continuity and integrity of the intestinal mucosa. The above characteristics of GLP-2 suggest that it has therapeutic potential for human diseases, especially intestinal diseases. This article reviews the biological characteristics of GLP-2 and its protective effect on intestinal mucosa.