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目的 了解新生儿病理性黄疸人类细小病毒B19感染情况及临床特征。方法 采用巢式聚合酶链反应(Nested PCR)技术对 130例病理性黄疸新生儿进行血液B19DNA检测 ,以同期 80例健康新生儿的血液作对照组。结果 130例新生儿病理性黄疸的血液B19DNA阳性率为 34 6 % (45 / 130 ) ,对照组为 8 8% (P <0 0 1)。在 4 5例B19阳性的新生儿病理性黄疸中有 2 5例为新生儿溶血性疾病 ,6例为头颅血肿 ,其余为感染性疾病 ;且具有贫血、出血、发热、皮疹等临床特点 ,少数病例出现一过性再障危象与多脏器功能损害。结论 ①细小病毒B19感染是新生儿病理性黄疸较重要的原因。②B19与新生儿病理性黄疸密切相关 ,且对病情与临床表现有一定的影响。
Objective To understand the infection status and clinical features of neonatal pathogenic jaundice human parvovirus B19. Methods Nested PCR was used to detect the blood B19DNA in 130 cases of pathological jaundice neonates. The blood of 80 healthy newborns was used as the control group. Results The positive rate of blood B19DNA in 130 neonates with pathologic jaundice was 34 6% (45/130) and that in the control group was 88% (P 0 01). In 45 cases of B19-positive neonatal pathological jaundice, 25 cases were neonatal hemolytic disease, 6 cases were cranial hematoma and the rest were infectious diseases. There were clinical features such as anemia, hemorrhage, fever and skin rash. A few Cases of transient aphasia crisis and multiple organ dysfunction. Conclusions ① Parvovirus B19 infection is the most important cause of neonatal pathological jaundice. ② B19 and neonatal pathological jaundice are closely related, and the disease and clinical manifestations have a certain impact.