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目的研究舌鳞状细胞癌(TSCC)组织中半乳糖凝集素-1(Gal-1)的表达及意义。方法对36例TSCC患者石蜡标本切片进行免疫组织化学染色,研究Gal-1的表达特点并结合临床资料探讨其与临床病理因素的关系。结果 Gal-1在TSCC组织中高表达,免疫组织化学染色主要定位于肿瘤及周围基质细胞胞浆;Gal-1的表达与肿瘤分化程度、区域淋巴结转移及肿瘤组织淋巴细胞浸润程度等因素相关。结论 Gal-1在TSCC发生发展及侵袭转移中具有重要作用,可望成为舌癌诊断和治疗的新靶点。
Objective To study the expression of galectin-1 (Gal-1) in tongue squamous cell carcinoma (TSCC) and its significance. Methods Immunohistochemical staining of paraffin specimens from 36 patients with TSCC was performed to study the expression of Gal-1 and to explore its relationship with clinicopathological factors. Results Gal-1 was highly expressed in TSCC tissues. Immunohistochemical staining was mainly located in cytoplasm of tumor and surrounding stromal cells. The expression of Gal-1 was related to the degree of tumor differentiation, regional lymph node metastasis and lymphocyte infiltration of tumor tissues. Conclusion Gal-1 plays an important role in the development, invasion and metastasis of TSCC, which is expected to become a new target for the diagnosis and treatment of tongue cancer.