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[目的]探讨血清甲胎蛋白(AFP)、血浆凝血酶原活动度(PTA)与血清前白蛋白(PALB)水平对慢加急性肝衰竭(ACLF)患者预后的影响。[方法]回顾性分析85例ACLF患者的临床资料,根据其临床转归分为生存组(45例)和死亡组(40例),比较2组AFP、PTA及PALB水平,分析这些指标与患者预后的关系。[结果]生存组AFP、PTA和PALB水平均明显高于死亡组(P<0.01),在不同水平AFP、PTA和PALB区间,生存组与死亡组发生率差异有统计学意义(P<0.01)。[结论]AFP、PTA和PALB水平与ACLF患者预后相关,检测这些指标有助于判断患者病情严重程度和预后转归。
[Objective] To investigate the influence of serum AFP, PTA and PALP on the prognosis of patients with acute and chronic liver failure (ACLF). [Methods] The clinical data of 85 ACLF patients were retrospectively analyzed. According to their clinical outcomes, 45 patients were divided into survival group and 40 death patients. The levels of AFP, PTA and PALB were compared between the two groups. Prognosis of the relationship. [Results] The levels of AFP, PTA and PALB in survival group were significantly higher than those in death group (P <0.01). There was significant difference in the incidence of death group and AFP, PTA and PALB between different levels (P <0.01) . [Conclusion] The levels of AFP, PTA and PALB are correlated with the prognosis of patients with ACLF. Detecting these indexes can help to determine the severity of the patients and prognosis.