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目的评价不同疗程口服伊曲康唑胶囊治疗复发性外阴阴道念珠菌病的临床疗效与安全性。方法计算机检索中国期刊全文数据库(1994-20011.11),中国生物医学文献数据库(1978-20011.11),维普中文期刊数据库(1989-2011.11),PUBMED(1966-2011.11),EMBASE(1974-2011.11)和The Cochrane Library(2011.4)。纳入口服伊曲康唑治疗复发性外阴阴道念珠菌病的随机对照试验(RCT),并评价纳入研究的方法学质量,用Revman5.1软件进行统计学处理。结果纳入8个RCT,包括511例患者。Meta分析表明,短程冲击联合长期预防性间断服用伊曲康唑治疗复发性外阴阴道念珠菌病复发率低于单纯短程冲击疗法。结论与单纯短程口服伊曲康唑相比,联合长期间断预防服用伊曲康唑效果更优,复发率联合用药组更低。
Objective To evaluate the clinical efficacy and safety of oral itraconazole capsules in the treatment of recurrent vulvovaginal candidiasis. Methods Chinese Journal Full-text Database (1994-20011.11), Chinese Biomedical Literature Database (1978-20011.11), VIP Chinese Periodical Database (1989-2011.11), PUBMED (1966-2011.11), EMBASE (1974-2011.11) and The Cochrane Library (2011.4). Randomized controlled trials (RCTs) of oral itraconazole in the treatment of recurrent vulvovaginal candidiasis were included, and the methodological quality of the included trials was evaluated and statistically analyzed using Revman 5.1 software. Results Eight RCTs were included, including 511 patients. Meta-analysis showed that short-term impact combined with long-term prophylactic intermittent administration of itraconazole in the treatment of recurrent vulvovaginal candidiasis recurrence rate was lower than simple short-stroke therapy. Conclusion Compared with simple short-term oral itraconazole, combination of long-term discontinuation of itraconazole is more effective and the relapse rate is lower in combination group.