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氨基忒类抗生素的耳毒性副作用早在四十年代就已被发现，然而这种毒副作用的机理在很长时期内却未曾明确。近来的研究表明，这种毒副作用是通过产生自由基实现的．使用自由基清除剂能有效地保护耳蜗毛细胞免遭氨基式类抗生素产生的自由基的毒害。越来越多的证据显示：2（）i＋Z
The ototoxic side effects of aminotetrazole have been discovered as early as the 1940s. However, the mechanism of this toxic side effect has not been clear for a long time. Recent research shows that this toxic side effect is achieved by generating free radicals. The use of free radical scavengers can effectively protect cochlear hair cells from the free radicals produced by the amino antibiotics. More and more evidence shows: 2 () i + Z