本文在大鼠气管灌注石英砂制造肺纤维痕瘢、在此基础上再经气管灌注化学致癌物质3—MC,可见此种实验组动物的肺癌发生率与对照组(单纯灌注3—MC)有显著差异。实验组动物共发生二例高分化鳞癌,一例腺癌,一例肺泡细胞癌。在腺癌的实验例明显看到在纤维性瘢痕组织癌内腺样组织增生及癌变。本文结果从动物实验上进一步证明了矽肺瘢痕的促癌作用。 In this study, rat tracheal perfusion of quartz sand was used to make traces of lung fibers, and then on the basis of tracheal infusion of chemical carcinogen 3-MC. The incidence of lung cancer in this experimental group was comparable to that of the control group (perfusion only 3-MC). Significant differences. There were two cases of well-differentiated squamous cell carcinoma, one case of adenocarcinoma, and one case of alveolar cell carcinoma in the experimental animals. In the experimental cases of adenocarcinoma, it was evident that adenoid tissue hyperplasia and canceration occurred in fibrous scar tissue. The results of this article further demonstrate the carcinogenic effect of silicosis scars from animal experiments.