论文部分内容阅读
目的探讨高三尖杉酯碱(HHT)联合全反式维甲酸(ATRA)及三氧化二砷(AS2O3)治疗急性早幼粒细胞白血病(APL)的疗效。方法根据治疗方案将95例APL患者分为观察组(51例)与对照组(44例),观察组患者接受HHT、ATRA、AS2O3三联方案治疗,对照组患者接受去甲氧柔红霉素(IDA)、ATRA、AS2O3三联方案治疗,现对比分析两组患者的疗效。结果①两组患者完全缓解率、获得完全缓解时间相比差异无统计学意义(P>0.05)。②两组患者肝功能损害、颜面部水肿、胃肠道反应、维甲酸综合征、头痛发生率相比差异无统计学意义(P>0.05),观察组患者骨髓Ⅲ~Ⅳ级抑制、感染发生率显著低于对照组(P<0.05)。结论 HHT联合ATRA及AS2O3治疗APL具有骨髓抑制较轻、感染发生率低等优点。
Objective To investigate the efficacy of homoharringtonine (HHT) combined with all-trans retinoic acid (ATRA) and arsenic trioxide (AS2O3) in the treatment of acute promyelocytic leukemia (APL). Methods 95 patients with APL were divided into observation group (51 cases) and control group (44 cases) according to the treatment plan. Patients in observation group were treated with triple therapy of HHT, ATRA and AS2O3. Patients in control group received dextromethorphan IDA), ATRA, AS2O3 triple therapy, the efficacy of two groups of patients were compared. Results ① There was no significant difference between the two groups in complete remission rate and complete remission (P> 0.05). ② There was no significant difference in the incidence of hepatic dysfunction, facial and facial edema, gastrointestinal tract reaction, retinoic acid syndrome and headache between the two groups (P> 0.05). Patients in the observation group had Ⅲ ~ Ⅳ levels of bone marrow suppression and infection The rate was significantly lower than that of the control group (P <0.05). Conclusion HHT combined with ATRA and AS2O3 in treating APL has the advantages of less myelosuppression and lower infection rate.