论文部分内容阅读
目的:观察雌激素的不同起始时间对子宫内膜厚度的影响及对冻融胚胎复苏移植FET(frozen-thawed embryotransfer)结局的影响。方法:采用前瞻性随机的方法,将雌激素准备子宫内膜方案患者(共702周期)分为A组(D1用药)和B组(D5用药),比较两组应用黄体酮转化子宫内膜日(简称P日)子宫内膜厚度、P日前雌激素的总剂量及持续时间、妊娠率及流产率等指标,同时评估子宫内膜厚度与FET结局的关系。结果:A、B两组P日的子宫内膜厚度分别为(8.8±1.23)mm和(9.14±1.40)mm,P日前雌激素的总剂量及持续时间A组为(83.97±37.5)mg和(15.83±3.01)天,B组为(67.42±26.19)mg和(11.40±2.81)天,两组比较差异均有统计学意义(P<0.05);妊娠率、流产率A、B两组分别为(45.1%VS47.1%)、(6.1%VS6.7%),两组差异均无统计学意义(P>0.05)。结论:雌激素不同起始时间准备子宫内膜的方案对FET结局无明显影响;B组方案获得的内膜厚度更为理想,更能模拟生理,更有利于子宫内膜的生长。
Objective: To observe the effect of different starting time of estrogen on endometrial thickness and its effect on frozen-thawed embryo transfer (FET). METHODS: A prospective randomized trial of estrogen-ready endometrial (702 cycles) was divided into group A (D1) and group B (D5), and the progesterone converting endometrial day (P day) endometrial thickness, the total dose and duration of estrogen P day ago, pregnancy rate and abortion rate and other indicators, while assessing the relationship between endometrial thickness and FET outcome. Results: The endometrial thickness of group A and B on day P were (8.8 ± 1.23) mm and (9.14 ± 1.40) mm, respectively. The total dose and duration of estrogen on day P were (83.97 ± 37.5) mg and (15.83 ± 3.01) days in group B, and (67.42 ± 26.19) mg and (11.40 ± 2.81) days in group B respectively. The difference between the two groups was statistically significant (P <0.05) (45.1% VS47.1%), (6.1% VS6.7%). There was no significant difference between the two groups (P> 0.05). CONCLUSION: The preparation of endometrium by estrogen at different initial time has no obvious effect on the outcome of FET. The thickness of endometrium obtained by group B is more ideal, and more able to simulate physiology, which is more beneficial to the growth of endometrium.