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应用核仁组成区染色技术系统地研究了正常胃粘膜、胃粘膜异型增生，早期胃癌及进展期胃癌的核仁组成区（AgNOR）数量和形态变化，发现正常胃粘膜AgNOR计数最低，形态无畸形，随着胃粘膜病变的进展，AgNOR计数逐渐升高，且形态上的畸形程度也随之增加。AgNOR计数与胃癌的浸润深度呈正相关，与胃癌的组织分化程度呈负相关，高AgNOR计数的胃癌易发生淋巴结转移。本研究结果提示，用AgNOR计数法，同时结合AgNOR畸形度，对鉴别中、重度胃粘膜异型增生与早期胃癌有一定帮助，且AgNOR计数有可能作为判断胃癌生物学行为的一个定量性指标。
The nucleolar staining technique was used to systematically study the number and morphological changes of normal nucleus, gastric mucosa dysplasia, early gastric cancer and advanced gastric cancer, and found that the normal AgNOR count was the lowest, and the morphology was not abnormal. With the progression of gastric mucosal lesions, the AgNOR count gradually increased, and the degree of morphological deformity also increased. AgNOR counts were positively correlated with the depth of invasion of gastric cancer and negatively correlated with the degree of tissue differentiation of gastric cancer. High AgNOR counts of gastric cancer were prone to lymph node metastasis. The results of this study suggest that using AgNOR count method combined with AgNOR deformity can help identify moderate and severe gastric dysplasia and early gastric cancer, and AgNOR count may be used as a quantitative indicator to determine the biological behavior of gastric cancer.