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以ＦＶＡ病毒诱导ＢＡＬＢ／ｃ小鼠脾细胞形成的红系细胞（ｅｒｙｔｈｒｏｉｄｃｅｌ）为研究对象，在红系细胞凋亡抑制剂——红细胞生成素（ＥＰＯ）存在情况下，观察了地塞米松（Ｄｅｘ）对上述细胞凋亡的诱导作用。结果表明，在一定浓度范围内，随着Ｄｅｘ作用时间的延长，细胞逐步凋亡并出现特有的ＤＮＡ梯形（ＤＮＡｌａｄｄｅｒ），而且其ＤＮＡ断裂程度与Ｄｅｘ的作用浓度呈正相关。透射电镜的结果证实，经最适浓度（５×１０－５ｍｏｌ／Ｌ）Ｄｅｘ处理后，红系细胞出现核固缩，染色质凝聚，核周隙扩大，核破裂，胞浆近膜处出现空泡以及细胞破碎等程度不同的细胞凋亡特征。说明Ｄｅｘ可拮抗ＥＰＯ的作用，有效地诱导红系细胞凋亡
The erythroidcels induced by FVA virus in BALB / c mice spleen cells were studied. Dexamethasone (Dex) was observed in the presence of erythropoietin (EPO) ) On the induction of apoptosis. The results showed that in a certain concentration range, with the prolonged action of Dex, the cells gradually became apoptotic and showed a unique DNA ladder, and the DNA fragmentation was positively correlated with the concentration of Dex. Transmission electron microscopy results confirmed that the optimal concentration (5 × 10-5mol / L) Dex treatment, erythroid cells nuclear pyknosis, chromatin condensation, perinuclear space expansion, nucleus rupture, cytoplasmatic near empty space Bubble and cell disruption to varying degrees of apoptosis characteristics. Dex can antagonize the role of EPO, effectively induced erythroid apoptosis