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目的:对多次单采血小板捐献者体内储存铁检测值进行分析,探讨不同献血周期对捐献者身体健康的影响。方法:选择各年龄多次单采血小板捐献者236名,其年龄、体格检查和血液检验均符合我国法规要求,对其外周血SI、SF检测值进行统计学分析研究。结果:与首次献血组相比,平均献PLT间隔为2周组的SF和SI值差异具有统计学意义(P<0.05),献血小板间隔3周组的SF值和SI值差异具有统计学意义(P<0.05)。结论:对于50周岁以上的长期固定捐献者和生育期的女性捐献者,每隔2~3周捐献1次单采血小板可能会引起献血者医源性铁缺乏,献血时应加强对MCV、RDW的关注,必要时测定SF含量,以排除隐性铁缺乏者,筛选出适合的单采血小板捐献者。
OBJECTIVE: To analyze the in vivo storage iron detection values of multiple apheresis donors to investigate the effects of different donation cycles on the donors’ health. Methods: Totally 236 apheresis donors of all ages were selected. Their age, physical examination and blood test all met the requirements of Chinese laws and regulations, and their SI and SF values in peripheral blood were statistically analyzed. Results: Compared with the first blood donation group, the difference between SF and SI values in mean PLT interval of 2 weeks was statistically significant (P <0.05), and SF and SI values in PLT group were statistically significant (P <0.05). CONCLUSIONS: For long-term fixed donors over 50 years of age and female donors during their reproductive age, donating a single apheresis plate every 2 to 3 weeks may cause iatrogenic iron deficiency in blood donors. Blood donation should be strengthened for MCV, RDW Of concern, if necessary, determination of SF content to rule out the presence of latent iron deficiency, screening suitable apheresis platelet donors.