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目的了解重庆市某区2009-2011年中小学生完成乙肝疫苗补种活动后6~24个月内的乙肝免疫水平现况,为进一步制定免疫控制策略提供科学依据。方法本研究于2012年采用容量比概率抽样方法,随机抽取重庆市某区参加2009-2011年乙肝疫苗补种的6~14岁中小学生进行问卷及静脉血采样,用ELISA法对乙肝五项免疫标志物进行检测,以单纯(抗-HBs)阳性作为具有免疫力为标准。分析不同接种针剂次人群补种后乙肝抗-HBs阳性率。结果共最终获得样本2 956份,该人群补种后只接种一针剂次人群的乙肝抗-HBs阳性率为58.69%,只接种二针剂次人群的乙肝抗-HBs阳性率为64.58%,三针剂次全程接种人群为79.73%,未参种人群为49.31%三针次阳性率明显高于二针次、一针次阳性率(分别χ2=17.05,P=0.0006;χ2=25.15,P=0.00001),一针次阳性率明显高于未参种人群阳性率(χ2=5.71,P=0.018)。标化后,参种人群乙肝抗-HBs总体阳性率为74.74%,未参种人群为49.31%,种后整个中小学生总体阳性率58.02%,参种后该人群总体阳性率显著高于未参种人群(χ2=36.19,P=0.0009)。结论重庆市某区2009-2011年在中小学开展乙肝疫苗补种活动后显著提高了本地区中小学生的乙肝整体免疫水平,但与其他普种地区相比还有较大差距,距离75%以上的免疫控制屏障水平还有15%的巨大提升空间。
Objective To understand the status of hepatitis B immunity in primary and secondary school students in Chongqing from 6 months to 24 months after completion of hepatitis B vaccination campaign in 2009-2011 in a district of Chongqing, so as to provide a scientific basis for further development of immune control strategy. Methods In this study, a volume-to-probability ratio sampling method was used in 2012 to randomly choose questionnaires and venous blood samples from 6-14-year-old primary and secondary school students who participated in the replanting of hepatitis B vaccine in Chongqing from 2009 to 2011. Five immunizations of hepatitis B Markers were tested as pure (anti-HBs) positive as having immunity as a standard. To analyze the positive rate of anti-HBs after hepatitis B vaccination vaccination. Results A total of 2 956 samples were finally obtained. The positive rate of anti-HBs was 58.69% in those vaccinated with only one injection and 64.58% in those with only two injections. The positive rate of anti-HBs was only 64.58% The positive rate of three-needle inoculation was 79.73% in the whole course and 49.31% in the non-participating group, which was significantly higher than that in the second and the second needle (χ2 = 17.05, P = 0.0006, χ2 = 25.15, , The positive rate of one stitch was significantly higher than that of the non-swine (χ2 = 5.71, P = 0.018). After standardization, the positive rate of anti-HBs was 74.74% in total and 49.31% in non-participating groups. The positive rate of the whole primary and secondary school students was 58.02% The population (χ2 = 36.19, P = 0.0009). Conclusion The immunization of hepatitis B in primary and secondary schools in primary and secondary schools in a district of Chongqing in 2009-2011 significantly increased the overall level of hepatitis B immunization, but there was still a big gap compared with other general areas, with a distance of more than 75% There is still a huge 15% improvement in immunity control barrier levels.