论文部分内容阅读
目的观察雌激素联合甲硝唑治疗萎缩性阴道炎的临床疗效。方法选取医院2014年6月-2016年8月收治的萎缩性阴道炎患者90例。随机分为甲硝唑组和甲硝唑+雌激素组各45例。甲硝唑组单纯用甲硝唑进行治疗,甲硝唑+雌激素组用甲硝唑联合雌激素治疗。比较2组患者萎缩性阴道炎干预效果;阴道壁充血缓解时间及瘙痒症状消退时间、异常白带消退时间;治疗前后患者子宫内膜厚度及阴道脱落细胞成熟指数。结果甲硝唑+雌激素组患者的总有效率为95.56%显著高于甲硝唑组的82.22%,差异有统计学意义(P<0.05),治疗前2组子宫内膜厚度、阴道脱落细胞成熟指数比较差异无统计学意义(P>0.05);治疗后2组子宫内膜厚度及阴道脱落细胞成熟指数均高于治疗前,且甲硝唑+雌激素组高于甲硝唑组,差异均有统计学意义(P<0.05)。甲硝唑+雌激素组患者阴道壁充血缓解时间、瘙痒症状消退时间及异常白带消退时间均短于甲硝唑组,差异有统计学意义(P<0.05)。结论雌激素联合甲硝唑治疗萎缩性阴道炎的临床疗效确切,可有效改善临床症状,促进子宫内膜厚度、阴道脱落细胞成熟指数的增加,缩短临床症状消退时间,值得推广。
Objective To observe the clinical efficacy of estrogen plus metronidazole in the treatment of atrophic vaginitis. Methods Ninety patients with atrophic vaginitis were selected from June 2014 to August 2016 in the hospital. Randomly divided into metronidazole group and metronidazole + estrogen group of 45 cases. Metronidazole group metronidazole treatment alone, metronidazole + estrogen group with metronidazole combined with estrogen treatment. The effect of atrophic vaginitis intervention was compared between the two groups. The time of remission of vaginal wall and the time of regression of pruritus, the time of abnormal leucorrhea, the thickness of endometrium and the index of maturation of vaginal exfoliated cells before and after treatment were compared. Results The total effective rate of metronidazole + estrogen group was 95.56%, which was significantly higher than that of metronidazole group (82.22%, P <0.05). The thickness of endometrium, vaginal exfoliated cells There was no significant difference in maturation index between the two groups (P> 0.05). After treatment, the thickness of endometrium and the maturation index of vaginal exfoliated cells in two groups were higher than those before treatment, and the metronidazole + estrogen group was higher than the metronidazole group All were statistically significant (P <0.05). The duration of vaginal wall hyperemia, the time to extinction of pruritus and the abnormal vaginal discharge in metronidazole + estrogen group were shorter than those in metronidazole group (P <0.05). Conclusion The clinical efficacy of estrogen and metronidazole in the treatment of atrophic vaginitis is exact, which can effectively improve the clinical symptoms, promote the increase of endometrial thickness, increase of maturity index of vaginal exfoliated cells and shorten the time of regression of clinical symptoms, which deserves promotion.